Clinical trials have shown that hyperthermia is a potent adjuvant to conventional cancer treatments, but the temperatures currently achieved in the clinic are still suboptimal. Hyperthermia treatment planning simulations have potential to improve the heating profile of phased-array applicators. An important open challenge is the development of an effective optimization procedure that enables uniform heating of the target region while keeping temperature below a threshold in healthy tissues. In this work, we analyzed the effectiveness and efficiency of a recently proposed optimization approach, i.e. focusing via constrained power optimization (FOCO), using 3D simulations of twelve clinical patient specific models. FOCO performance was compared against a clinically used particle swarm based optimization approach. Evaluation metrics were target coverage at the 25% iso-SAR level, target hotspot quotient, median target temperature (T50) and computational requirements. Our results show that, on average, constrained power focusing performs slightly better than the clinical benchmark (T50 °C), but outperforms this clinical benchmark for large target volumes (40 cm, T50 °C). In addition, the results are achieved in a shorter time (%) and are repeatable because the approach is formulated as a convex optimization problem.

The Potential of Constrained SAR Focusing for Hyperthermia Treatment Planning: Analysis for the Head & Neck Region / Bellizzi, Gg; Drizdal, T; Van Rhoon, G; Crocco, L; Isernia, Tommaso; Paulides, M.. - In: PHYSICS IN MEDICINE & BIOLOGY. - ISSN 1361-6560. - 64:015013(2019), pp. 1-10. [10.1088/1361-6560/aaf0c4]

The Potential of Constrained SAR Focusing for Hyperthermia Treatment Planning: Analysis for the Head & Neck Region

ISERNIA, Tommaso;
2019-01-01

Abstract

Clinical trials have shown that hyperthermia is a potent adjuvant to conventional cancer treatments, but the temperatures currently achieved in the clinic are still suboptimal. Hyperthermia treatment planning simulations have potential to improve the heating profile of phased-array applicators. An important open challenge is the development of an effective optimization procedure that enables uniform heating of the target region while keeping temperature below a threshold in healthy tissues. In this work, we analyzed the effectiveness and efficiency of a recently proposed optimization approach, i.e. focusing via constrained power optimization (FOCO), using 3D simulations of twelve clinical patient specific models. FOCO performance was compared against a clinically used particle swarm based optimization approach. Evaluation metrics were target coverage at the 25% iso-SAR level, target hotspot quotient, median target temperature (T50) and computational requirements. Our results show that, on average, constrained power focusing performs slightly better than the clinical benchmark (T50 °C), but outperforms this clinical benchmark for large target volumes (40 cm, T50 °C). In addition, the results are achieved in a shorter time (%) and are repeatable because the approach is formulated as a convex optimization problem.
2019
treatment planning, constrained optimization, convex programming, SAR
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12318/4646
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